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TRANSFORMING GROWTH FACTOR BETA2
Descriptors Found:
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DeCS
Descriptor
English
:
Transforming Growth Factor beta2
Descriptor
Spanish
:
Factor de Crecimiento Transformador beta2
Descriptor
Portuguese
:
Fator de Crescimento Transformador beta2
Synonyms
English
:
TGF-beta2
Tree Number:
D12.644.276.374.687.200
D12.644.276.954.775.200
D12.776.467.374.687.200
D12.776.467.942.775.200
D23.529.374.687.200
D23.529.942.775.200
Definition
English
:
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent
growth
of both helper and CYTOTOXIC T
LYMPHOCYTES
. It is synthesized as a precursor molecule that is cleaved to form mature
TGF-beta2
and
TGF-beta2
latency-associated peptide. The
association
of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
History Note
English
:
2007(2000)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52286
Unique Identifier:
D053781
Occurrence in VHL
:
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